Vitamin-dependent Gene Databases

 

This vitamin-dependent database lists all known gene products with domains using either vitamin B1 (thiamine), B2 (riboflavin), or B3 (niacin) as a co-factor or substrate (Penberthy, 2013).

 

One can search for their gene of interest within this webpage or download the spreadsheet at the end of this webpage. 

 

This is a continuously important resource as science continues to determine gene-functions and by extension vitamin B1-B3 functions. 

 

Genetic polymorphisms that reduce vitamin (derived) co-factor/substrate-binding affinity result in individuals whose lives can be saved, improved, or optimized by high-dose vitamin therapy (Ames, 2002). This is true for countless numbers of individuals. It costs almost nothing to do high-dose vitamin therapy and the safety profile is superior to most pharmaceuticals.  

 

It may be clinically significant to consider genetic polymorphisms in the genes containing NAD, thiamine, and/or riboflavin-binding domains. 

 

These databases were developed from my own research using UniproKB with the assistance of Dr. Kristian Axelsen of the Swiss Institute of Bioinformatics, 2012. 

 

Databases are freely available for download at the bottom of this page. 

 

Niacin is particularly impressive for many reasons not limited to the following. The biochemical end-product of niacin consumption,  nicotinamide adenine dinucleotide (NAD), is used a co-factor or substrate in more reactions than any other vitamin-derived co-factor, >450 reactions. A polymorphism in the NAD binding for any of these genes can cause an individual to require higher amounts of niacin to provide greater NAD concentrations. NAD is used in phase 1 drug metabolism, including basic alcohol metabolism, where the founder of Alcoholics Anonymous himself, Bill W, was a great proponent of its use in controlling alcoholism (Niacin Therapy as Used by Abram Hoffer). We know more about several mechanisms that specifically and actively trigger the depletion of NAD than we do for most vitamins (Penberthy, 2007; Penberthy, 2009). Niacin-related research continues to amaze, with the PARP, Sirtuin, CD38, drug metabolism fields, and more all giving perennial consideration to this amazing molecule. 

 

Thiamine, while only involved in roughly 30 different reactions, thiamine is essential for several central bioenergetic pathways that are particularly important in preventing neurodegeneration and powering the heart. Thiamine is distinguished as the heat-sensitive B vitamin. Absence of thiamine essentially causes the brain to rot and favorable results have been seen after high-dose administration for a variety of neurological conditions. Thiamine is routinely administered by injection to treat Wernicke-Korsakoff syndrome, which most frequently occurs in chronic alcoholics. Recovery from nystagmus can occur within minutes of injection. Most, unfortunately, thiamine research is woefully overlooked, but it makes sense as consideration for neurodegenerative diseases like Alzheimer's. 

 

Riboflavin is the most colorful vitamin. While it is difficult to achieve high doses of this B vitamin due to poor solubility, something is everything when it is essential. It is used in a wide range of reactions (>200). Unfortunately, the mechanisms of riboflavin depletion are poorly understood and this vitamin is generally understudied. 

 

 

Ames BN, Elson-Schwab I, Silver EA. High-dose vitamin therapy stimulates variant enzymes with decreased coenzyme binding affinity (increased K(m)): relevance to genetic disease and polymorphisms. Am J Clin Nutr. Apr 2002;75(4):616-658.

 

Penberthy WT. Niacin, Riboflavin, and Thiamine. In: Stipanuk MH, Caudill MA, eds. Biochemical, physiological, and molecular aspects of human nutrition. 3rd ed. St. Louis, Mo.: Elsevier/Saunders; 2013:p.540-564.

 

Penberthy WT. Pharmacological targeting of IDO-mediated tolerance for treating autoimmune disease. Curr Drug Metab. Apr 2007;8(3):245-266.

 

Penberthy WT, Tsunoda I. The importance of NAD in multiple sclerosis. Curr Pharm Des. 2009;15(1):64-99.

 

 

NAD(P(H))/VitB3 Dependent

 

 

Gene 

 

Protein Name

 

 

AASS

 

Alpha-aminoadipic semialdehyde synthase, mitochondrial (LKR/SDH) [Includes: Lysine ketoglutarate reductase (LKR) (LOR) (EC 1.5.1.8); Saccharopine dehydrogenase (SDH) (EC 1.5.1.9)]

 

 

ACMSD

 

2-amino-3-carboxymuconate-6-semialdehyde decarboxylase (EC 4.1.1.45) (Picolinate carboxylase)

 

 

ADH1A ADH1

 

Alcohol dehydrogenase 1A (EC 1.1.1.1) (Alcohol dehydrogenase subunit alpha)

 

 

ADH1B ADH2

 

Alcohol dehydrogenase 1B (EC 1.1.1.1) (Alcohol dehydrogenase subunit beta)

 

 

ADH1C ADH3

 

Alcohol dehydrogenase 1C (EC 1.1.1.1) (Alcohol dehydrogenase subunit gamma)

 

 

ADH4

 

Alcohol dehydrogenase 4 (EC 1.1.1.1) (Alcohol dehydrogenase class II pi chain)

 

 

ADH5 ADHX FDH

 

Alcohol dehydrogenase class-3 (EC 1.1.1.1) (Alcohol dehydrogenase class-III) (Alcohol dehydrogenase 5) (Alcohol dehydrogenase class chi chain) (S-(hydroxymethyl)glutathione dehydrogenase) (EC 1.1.1.284) (Glutathione-dependent formaldehyde dehydrogenase) (GSH-FDH) (FALDH) (FDH) (EC 1.1.1.-)

 

 

ADH6

 

Alcohol dehydrogenase 6 (EC 1.1.1.1)

 

 

ADH7

 

Alcohol dehydrogenase class 4 mu/sigma chain (EC 1.1.1.1) (Alcohol dehydrogenase class IV mu/sigma chain) (Retinol dehydrogenase) (Gastric alcohol dehydrogenase)

 

 

AFMID

 

Probable arylformamidase (EC 3.5.1.9) (Kynurenine formamidase) (KF)

 

 

AHCY SAHH

 

Adenosylhomocysteinase (AdoHcyase) (EC 3.3.1.1) (S-adenosyl-L-homocysteine hydrolase)

 

 

AHCYL1 DCAL XPVKONA

 

Putative adenosylhomocysteinase 2 (AdoHcyase 2) (EC 3.3.1.1) (S-adenosyl-L-homocysteine hydrolase 2) (S-adenosylhomocysteine hydrolase-like protein 1) (DC-expressed AHCY-like molecule)

 

 

AHCYL2 KIAA0828

 

Putative adenosylhomocysteinase 3 (AdoHcyase 3) (EC 3.3.1.1) (S-adenosyl-L-homocysteine hydrolase 3) (S-adenosylhomocysteine hydrolase-like protein 2)

 

 

AKR1A1 ALDR1 ALR

 

Alcohol dehydrogenase [NADP+] (EC 1.1.1.2) (Aldehyde reductase) (Aldo-keto reductase family 1 member A1)

 

 

AKR1B1 ALDR1

 

Aldose reductase (AR) (EC 1.1.1.21) (Aldehyde reductase) (Aldo-keto reductase family 1 member B1)

 

 

AKR1C1 DDH DDH1

 

Aldo-keto reductase family 1 member C1 (EC 1.1.1.-) (20-alpha-hydroxysteroid dehydrogenase) (20-alpha-HSD) (EC 1.1.1.149) (Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase) (EC 1.3.1.20) (Indanol dehydrogenase) (EC 1.1.1.112) (Dihydrodiol dehydrogenase 1/2) (DD1/DD2) (Chlordecone reductase homolog HAKRC) (High-affinity hepatic bile acid-binding protein) (HBAB)

 

 

AKR1C2 DDH2

 

Aldo-keto reductase family 1 member C2 (EC 1.-.-.-) (Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase) (EC 1.3.1.20) (Type III 3-alpha-hydroxysteroid dehydrogenase) (EC 1.1.1.213) (3-alpha-HSD3) (Dihydrodiol dehydrogenase 2) (DD-2) (DD2) (Dihydrodiol dehydrogenase/bile acid-binding protein) (DD/BABP) (Chlordecone reductase homolog HAKRD)

 

 

AKR1C3 DDH1 HSD17B5 KIAA0119 PGFS

 

Aldo-keto reductase family 1 member C3 (EC 1.-.-.-) (Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase) (EC 1.3.1.20) (3-alpha-hydroxysteroid dehydrogenase type 2) (3-alpha-HSD type 2) (EC 1.1.1.213) (3-alpha-HSD type II, brain) (Testosterone 17-beta-dehydrogenase 5) (EC 1.1.1.63) (EC 1.1.1.64) (17-beta-hydroxysteroid dehydrogenase type 5) (17-beta-HSD 5) (Prostaglandin F synthase) (PGFS) (EC 1.1.1.188) (Indanol dehydrogenase) (EC 1.1.1.112) (Dihydrodiol dehydrogenase type I) (Dihydrodiol dehydrogenase 3) (DD-3) (DD3) (Chlordecone reductase homolog HAKRb) (HA1753)

 

 

AKR1C4 CHDR

 

Aldo-keto reductase family 1 member C4 (EC 1.1.1.-) (Chlordecone reductase) (CDR) (EC 1.1.1.225) (3-alpha-hydroxysteroid dehydrogenase type I) (EC 1.1.1.50) (3-alpha-HSD1) (Dihydrodiol dehydrogenase 4) (DD-4) (DD4) (HAKRA)

 

 

AKR1D1 SRD5B1

 

3-oxo-5-beta-steroid 4-dehydrogenase (EC 1.3.1.3) (Delta(4)-3-ketosteroid 5-beta-reductase) (Delta(4)-3-oxosteroid 5-beta-reductase) (Aldo-keto reductase family 1 member D1)

 

 

AKR1E2 AKR1CL2 AKRDC1

 

1,5-anhydro-D-fructose reductase (AF reductase) (EC 1.1.1.263) (Aldo-keto reductase family 1 member C-like protein 2) (Aldo-keto reductase family 1 member E2) (Testis-specific protein) (hTSP) (LoopADR)

 

 

AKR7A2 AFAR AFAR1 AKR7

 

Aflatoxin B1 aldehyde reductase member 2 (EC 1.1.1.n11) (Succinic semialdehyde reductase) (SSA reductase) (AFB1 aldehyde reductase 1) (AFB1-AR 1) (Aldoketoreductase 7)

 

 

ALDH18A1 GSAS P5CS PYCS

 

Delta-1-pyrroline-5-carboxylate synthase (P5CS) (Aldehyde dehydrogenase family 18 member A1) [Includes: Glutamate 5-kinase (GK) (EC 2.7.2.11) (Gamma-glutamyl kinase); Gamma-glutamyl phosphate reductase (GPR) (EC 1.2.1.41) (Glutamate-5-semialdehyde dehydrogenase) (Glutamyl-gamma-semialdehyde dehydrogenase)]

 

 

ALDH1A1 ALDC ALDH1 PUMB1

 

Retinal dehydrogenase 1 (RALDH 1) (RalDH1) (EC 1.2.1.36) (Aldehyde dehydrogenase family 1 member A1) (Aldehyde dehydrogenase, cytosolic) (ALHDII) (ALDH-E1)

 

 

ALDH1A2 RALDH2

 

Retinal dehydrogenase 2 (RALDH 2) (RalDH2) (EC 1.2.1.36) (Aldehyde dehydrogenase family 1 member A2) (Retinaldehyde-specific dehydrogenase type 2) (RALDH(II))

 

 

ALDH1A3 ALDH6

 

Aldehyde dehydrogenase family 1 member A3 (EC 1.2.1.5) (Aldehyde dehydrogenase 6) (Retinaldehyde dehydrogenase 3) (RALDH-3) (RalDH3)

 

 

ALDH1B1 ALDH5 ALDHX

 

Aldehyde dehydrogenase X, mitochondrial (EC 1.2.1.3) (Aldehyde dehydrogenase family 1 member B1) (Aldehyde dehydrogenase 5)

 

 

ALDH1L1 FTHFD

 

10-formyltetrahydrofolate dehydrogenase (10-FTHFDH) (EC 1.5.1.6) (Aldehyde dehydrogenase family 1 member L1)

 

 

ALDH1L2

 

Probable 10-formyltetrahydrofolate dehydrogenase ALDH1L2 (EC 1.5.1.6) (Aldehyde dehydrogenase family 1 member L2)

 

 

ALDH2 ALDM

 

Aldehyde dehydrogenase, mitochondrial (EC 1.2.1.3) (ALDH class 2) (ALDHI) (ALDH-E2)

 

 

ALDH3A1 ALDH3

 

Aldehyde dehydrogenase, dimeric NADP-preferring (EC 1.2.1.5) (Aldehyde dehydrogenase family 3 member A1) (Aldehyde dehydrogenase 3) (ALDHIII)

 

 

ALDH3A2 ALDH10 FALDH

 

Fatty aldehyde dehydrogenase (EC 1.2.1.3) (Aldehyde dehydrogenase family 3 member A2) (Aldehyde dehydrogenase 10) (Microsomal aldehyde dehydrogenase)

 

 

ALDH3B1 ALDH7

 

Aldehyde dehydrogenase family 3 member B1 (EC 1.2.1.5) (Aldehyde dehydrogenase 7)

 

 

ALDH3B2 ALDH8

 

Aldehyde dehydrogenase family 3 member B2 (EC 1.2.1.5) (Aldehyde dehydrogenase 8)

 

 

ALDH4A1 ALDH4 P5CDH

 

Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial (P5C dehydrogenase) (EC 1.5.1.12) (Aldehyde dehydrogenase family 4 member A1)

 

 

ALDH5A1 SSADH

 

Succinate-semialdehyde dehydrogenase, mitochondrial (EC 1.2.1.24) (NAD(+)-dependent succinic semialdehyde dehydrogenase) (Aldehyde dehydrogenase family 5 member A1)

 

 

ALDH6A1 MMSDH

 

Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial (Malonate-semialdehyde dehydrogenase [acylating]) (MMSDH) (EC 1.2.1.27) (EC 1.2.1.18) (Aldehyde dehydrogenase family 6 member A1)

 

 

ALDH7A1 ATQ1

 

Alpha-aminoadipic semialdehyde dehydrogenase (Alpha-AASA dehydrogenase) (EC 1.2.1.31) (Betaine aldehyde dehydrogenase) (EC 1.2.1.8) (Delta1-piperideine-6-carboxylate dehydrogenase) (P6c dehydrogenase) (Aldehyde dehydrogenase family 7 member A1) (EC 1.2.1.3) (Antiquitin-1)

 

 

ALDH8A1 ALDH12

 

Aldehyde dehydrogenase family 8 member A1 (EC 1.2.1.-) (Aldehyde dehydrogenase 12)

 

 

ALDH9A1 ALDH4 ALDH7 ALDH9

 

4-trimethylaminobutyraldehyde dehydrogenase (TMABADH) (EC 1.2.1.47) (Aldehyde dehydrogenase family 9 member A1) (EC 1.2.1.3) (Aldehyde dehydrogenase E3 isozyme) (Gamma-aminobutyraldehyde dehydrogenase) (EC 1.2.1.19) (R-aminobutyraldehyde dehydrogenase)

 

 

ART1

 

GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1 (EC 2.4.2.31) (Mono(ADP-ribosyl)transferase 1) (CD antigen CD296)

 

 

ART3 TMART

 

Ecto-ADP-ribosyltransferase 3 (EC 2.4.2.31) (NAD(P)(+)--arginine ADP-ribosyltransferase 3) (Mono(ADP-ribosyl)transferase 3)

 

 

ART4 DO DOK1

 

Ecto-ADP-ribosyltransferase 4 (EC 2.4.2.31) (NAD(P)(+)--arginine ADP-ribosyltransferase 4) (Mono(ADP-ribosyl)transferase 4) (Dombrock blood group carrier molecule) (CD antigen CD297)

 

 

ART5 UNQ575/PRO1137

 

Ecto-ADP-ribosyltransferase 5 (EC 2.4.2.31) (NAD(P)(+)--arginine ADP-ribosyltransferase 5) (Mono(ADP-ribosyl)transferase 5)

 

 

ASPDH

 

Putative L-aspartate dehydrogenase (EC 1.4.1.21) (Aspartate dehydrogenase domain-containing protein)

 

 

ASPDH

 

Putative L-aspartate dehydrogenase (EC 1.4.1.21) (Aspartate dehydrogenase domain-containing protein)

 

 

BDH1 BDH

 

D-beta-hydroxybutyrate dehydrogenase, mitochondrial (BDH) (EC 1.1.1.30) (3-hydroxybutyrate dehydrogenase)

 

 

BDH2 DHRS6 UNQ6308/PRO20933

 

3-hydroxybutyrate dehydrogenase type 2 (EC 1.1.1.30) (R-beta-hydroxybutyrate dehydrogenase) (Dehydrogenase/reductase SDR family member 6) (Oxidoreductase UCPA)

 

 

BLVRA BLVR BVR

 

Biliverdin reductase A (BVR A) (EC 1.3.1.24) (Biliverdin-IX alpha-reductase)

 

 

BLVRB FLR

 

Flavin reductase (FR) (EC 1.5.1.30) (NADPH-dependent diaphorase) (NADPH-flavin reductase) (FLR) (Biliverdin reductase B) (BVR-B) (EC 1.3.1.24) (Biliverdin-IX beta-reductase) (Green heme-binding protein) (GHBP)

 

 

BST1

 

ADP-ribosyl cyclase 2 (EC 3.2.2.5) (Cyclic ADP-ribose hydrolase 2) (cADPr hydrolase 2) (Bone marrow stromal antigen 1) (BST-1) (CD antigen CD157)

 

 

C8orf38

 

UPF0551 protein C8orf38, mitochondrial (Putative phytoene synthase)

 

 

CAT

 

Catalase (EC 1.11.1.6)

 

 

CBR1 CBR CRN

 

Carbonyl reductase [NADPH] 1 (EC 1.1.1.184) (NADPH-dependent carbonyl reductase 1) (Prostaglandin-E(2) 9-reductase) (EC 1.1.1.189) (Prostaglandin 9-ketoreductase) (15-hydroxyprostaglandin dehydrogenase [NADP+]) (EC 1.1.1.197)

 

 

CBR3

 

Carbonyl reductase [NADPH] 3 (EC 1.1.1.184) (NADPH-dependent carbonyl reductase 3)

 

 

CBR4

 

Carbonyl reductase family member 4 (EC 1.-.-.-) (Quinone reductase CBR4) (3-oxoacyl-[acyl-carrier-protein] reductase) (EC 1.1.1.-)

 

 

CD38

 

ADP-ribosyl cyclase 1 (EC 3.2.2.5) (Cyclic ADP-ribose hydrolase 1) (cADPr hydrolase 1) (T10) (CD antigen CD38)

 

 

CRYL1 CRY

 

Lambda-crystallin homolog (EC 1.1.1.45) (L-gulonate 3-dehydrogenase) (Gul3DH)

 

 

CRYZ

 

Quinone oxidoreductase (EC 1.6.5.5) (NADPH:quinone reductase) (Zeta-crystallin)

 

 

CTBP1 CTBP

 

C-terminal-binding protein 1 (CtBP1) (EC 1.1.1.-)

 

 

CYB5B CYB5M OMB5

 

Cytochrome b5 type B (Cytochrome b5 outer mitochondrial membrane isoform)

 

 

CYB5R1 NQO3A2 UNQ3049/PRO9865

 

NADH-cytochrome b5 reductase 1 (b5R.1) (EC 1.6.2.2) (NAD(P)H:quinone oxidoreductase type 3 polypeptide A2) (Humb5R2)

 

 

CYB5R2

 

NADH-cytochrome b5 reductase 2 (b5R.2) (EC 1.6.2.2)

 

 

CYB5R3 DIA1

 

NADH-cytochrome b5 reductase 3 (Cytochrome b5 reductase) (B5R) (EC 1.6.2.2) (Diaphorase-1) [Cleaved into: NADH-cytochrome b5 reductase 3 membrane-bound form; NADH-cytochrome b5 reductase 3 soluble form]

 

 

CYB5R4 NCB5OR

 

Cytochrome b5 reductase 4 (EC 1.6.2.2) (Flavohemoprotein b5/b5R) (b5+b5R) (cb5/cb5R) (N-terminal cytochrome b5 and cytochrome b5 oxidoreductase domain-containing protein)

 

 

CYB5RL

 

NADH-cytochrome b5 reductase-like (EC 1.6.2.2)

 

 

CYBA

 

Cytochrome b-245 light chain (p22 phagocyte B-cytochrome) (Neutrophil cytochrome b 22 kDa polypeptide) (p22-phox) (p22phox) (Cytochrome b(558) alpha chain) (Cytochrome b558 subunit alpha) (Superoxide-generating NADPH oxidase light chain subunit)

 

 

CYBB NOX2

 

Cytochrome b-245 heavy chain (EC 1.-.-.-) (p22 phagocyte B-cytochrome) (Neutrophil cytochrome b 91 kDa polypeptide) (Heme-binding membrane glycoprotein gp91phox) (CGD91-phox) (gp91-phox) (gp91-1) (Cytochrome b(558) subunit beta) (Cytochrome b558 subunit beta) (Superoxide-generating NADPH oxidase heavy chain subunit) (NADPH oxidase 2)

 

 

CYP1A1

 

Cytochrome P450 1A1 (EC 1.14.14.1) (CYPIA1) (Cytochrome P450-P1) (Cytochrome P450 form 6) (Cytochrome P450-C)

 

 

CYP1A2

 

Cytochrome P450 1A2 (EC 1.14.14.1) (CYPIA2) (Cytochrome P450-P3) (Cytochrome P(3)450) (Cytochrome P450 4)

 

 

CYP1B1

 

Cytochrome P450 1B1 (EC 1.14.14.1) (CYPIB1)

 

 

CYP24A1 CYP24

 

1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial (Vitamin D(3) 24-hydroxylase) (24-OHase) (EC 1.14.13.n4) (Cytochrome P450 24A1) (Cytochrome P450-CC24)

 

 

CYP27A1 CYP27

 

Sterol 26-hydroxylase, mitochondrial (EC 1.14.13.15) (Cytochrome P450 27) (Cytochrome P-450C27/25) (Sterol 27-hydroxylase) (Vitamin D(3) 25-hydroxylase) (5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol 27-hydroxylase)

 

 

CYP27B1 CYP1ALPHA CYP27B

 

25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial (EC 1.14.13.13) (Cytochrome P450 subfamily XXVIIB polypeptide 1) (Cytochrome p450 27B1) (Calcidiol 1-monooxygenase) (25-OHD-1 alpha-hydroxylase) (25-hydroxyvitamin D(3) 1-alpha-hydroxylase) (VD3 1A hydroxylase) (Cytochrome P450C1 alpha) (Cytochrome P450VD1-alpha)

 

 

CYP2A7

 

Cytochrome P450 2A7 (EC 1.14.14.1) (CYPIIA7) (Cytochrome P450 IIA4)

 

 

CYP2B6

 

Cytochrome P450 2B6 (EC 1.14.14.1) (CYPIIB6) (Cytochrome P450 IIB1)

 

 

CYP2C19

 

Cytochrome P450 2C19 ((R)-limonene 6-monooxygenase) (EC 1.14.13.80) ((S)-limonene 6-monooxygenase) (EC 1.14.13.48) ((S)-limonene 7-monooxygenase) (EC 1.14.13.49) (CYPIIC19) (Cytochrome P450-11A) (Mephenytoin 4-hydroxylase) (CYPIIC17) (Cytochrome P450-254C)

 

 

CYP2C8

 

Cytochrome P450 2C8 (EC 1.14.14.1) (CYPIIC8) (Cytochrome P450 form 1) (Cytochrome P450 MP-12) (Cytochrome P450 MP-20) (Cytochrome P450 IIC2) (S-mephenytoin 4-hydroxylase)

 

 

CYP2C9 CYP2C10

 

Cytochrome P450 2C9 ((R)-limonene 6-monooxygenase) (EC 1.14.13.80) ((S)-limonene 6-monooxygenase) (EC 1.14.13.48) ((S)-limonene 7-monooxygenase) (EC 1.14.13.49) (CYPIIC9) (Cytochrome P450 PB-1) (Cytochrome P450 MP-4) (Cytochrome P450 MP-8) (S-mephenytoin 4-hydroxylase) (Cytochrome P-450MP)

 

 

CYP2E1 CYP2E

 

Cytochrome P450 2E1 (EC 1.14.13.-) (CYPIIE1) (4-nitrophenol 2-hydroxylase) (EC 1.14.13.n7) (Cytochrome P450-J)

 

 

CYP2J2

 

Cytochrome P450 2J2 (EC 1.14.14.1) (CYPIIJ2) (Arachidonic acid epoxygenase)

 

 

CYP2R1

 

Vitamin D 25-hydroxylase (EC 1.14.13.15) (Cytochrome P450 2R1)

 

 

CYP39A1

 

24-hydroxycholesterol 7-alpha-hydroxylase (Oxysterol 7-alpha-hydroxylase) (EC 1.14.13.99) (Cytochrome P450 39A1) (hCYP39A1)

 

 

CYP3A4 CYP3A3

 

Cytochrome P450 3A4 (Quinine 3-monooxygenase) (EC 1.14.13.67) (CYPIIIA4) (Nifedipine oxidase) (Cytochrome P450 3A3) (CYPIIIA3) (Cytochrome P450 HLp) (Taurochenodeoxycholate 6-alpha-hydroxylase) (EC 1.14.13.97) (Cytochrome P450 NF-25) (Cytochrome P450-PCN1) (Albendazole monooxygenase) (EC 1.14.13.32) (Albendazole sulfoxidase)

 

 

CYP3A5

 

Cytochrome P450 3A5 (EC 1.14.14.1) (CYPIIIA5) (Cytochrome P450-PCN3) (Cytochrome P450 HLp2)

 

 

CYP3A7

 

Cytochrome P450 3A7 (EC 1.14.14.1) (CYPIIIA7) (Cytochrome P450-HFLA)

 

 

CYP46A1 CYP46

 

Cholesterol 24-hydroxylase (CH24H) (EC 1.14.13.98) (Cytochrome P450 46A1)

 

 

CYP4B1

 

Cytochrome P450 4B1 (EC 1.14.14.1) (CYPIVB1) (Cytochrome P450-HP)

 

 

CYP4F2

 

Leukotriene-B(4) omega-hydroxylase 1 (EC 1.14.13.30) (Cytochrome P450 4F2) (CYPIVF2) (Leukotriene-B(4) 20-monooxygenase 1) (Cytochrome P450-LTB-omega)

 

 

CYP4F3 LTB4H

 

Leukotriene-B(4) omega-hydroxylase 2 (EC 1.14.13.30) (Cytochrome P450 4F3) (CYPIVF3) (Leukotriene-B(4) 20-monooxygenase 2) (Cytochrome P450-LTB-omega)

 

 

CYP51A1 CYP51

 

Lanosterol 14-alpha demethylase (LDM) (EC 1.14.13.70) (Cytochrome P450 51A1) (CYPLI) (Cytochrome P450LI) (Sterol 14-alpha demethylase) (Cytochrome P450-14DM) (Cytochrome P45014DM)

 

 

CYP7A1 CYP7

 

Cholesterol 7-alpha-monooxygenase (EC 1.14.13.17) (Cytochrome P450 7A1) (CYPVII) (Cholesterol 7-alpha-hydroxylase)

 

 

CYP7B1

 

25-hydroxycholesterol 7-alpha-hydroxylase (Oxysterol 7-alpha-hydroxylase) (EC 1.14.13.100) (Cytochrome P450 7B1)

 

 

CYP8B1 CYP12

 

7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase (EC 1.14.13.95) (Cytochrome P450 8B1) (CYPVIIIB1) (7-alpha-hydroxy-4-cholesten-3-one 12-alpha-hydroxylase) (Sterol 12-alpha-hydroxylase)

 

 

DCXR

 

L-xylulose reductase (XR) (EC 1.1.1.10) (Dicarbonyl/L-xylulose reductase) (Kidney dicarbonyl reductase) (kiDCR) (Carbonyl reductase II) (Sperm surface protein P34H)

 

 

DECR1 DECR

 

2,4-dienoyl-CoA reductase, mitochondrial (EC 1.3.1.34) (2,4-dienoyl-CoA reductase [NADPH]) (4-enoyl-CoA reductase [NADPH])

 

 

DECR2 PDCR

 

Peroxisomal 2,4-dienoyl-CoA reductase (pDCR) (EC 1.3.1.34) (2,4-dienoyl-CoA reductase 2)

 

 

DHCR7 D7SR

 

7-dehydrocholesterol reductase (7-DHC reductase) (EC 1.3.1.21) (Sterol Delta(7)-reductase) (Putative sterol reductase SR-2)

 

 

DHDH 2DD

 

Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase (EC 1.3.1.20) (Dimeric dihydrodiol dehydrogenase) (D-xylose-NADP dehydrogenase) (EC 1.1.1.179) (D-xylose 1-dehydrogenase) (Hum2DD)

 

 

DHFR; DHFRP1

 

Dihydrofolate reductase (EC 1.5.1.3)

 

 

DHPS DS

 

Deoxyhypusine synthase (DHS) (EC 2.5.1.46)

 

 

DHRS2

 

Dehydrogenase/reductase SDR family member 2 (EC 1.1.1.-) (Protein D) (Dicarbonyl reductase HEP27)

 

 

DHRS3 UNQ2424/PRO4983

 

Short-chain dehydrogenase/reductase 3 (EC 1.1.1.300) (Retinal short-chain dehydrogenase/reductase 1) (retSDR1) (DD83.1)

 

 

DHRS4 UNQ851/PRO1800

 

Dehydrogenase/reductase SDR family member 4 (EC 1.1.1.184) (Short-chain dehydrogenase/reductase family member 4) (NADPH-dependent carbonyl reductase/NADP-retinol dehydrogenase) (PHCR) (CR) (Peroxisomal short-chain alcohol dehydrogenase) (PSCD) (NADPH-dependent retinol dehydrogenase/reductase) (NRDR) (humNRDR) (SCAD-SRL)

 

 

DHRS9 UNQ835/PRO1773

 

Dehydrogenase/reductase SDR family member 9 (EC 1.1.-.-) (3-alpha hydroxysteroid dehydrogenase) (3-alpha-HSD) (Short-chain dehydrogenase/reductase retSDR8) (NADP-dependent retinol dehydrogenase/reductase) (RDH-E2) (RDHL)

 

 

DLD GCSL LAD PHE3

 

Dihydrolipoyl dehydrogenase, mitochondrial (EC 1.8.1.4) (Dihydrolipoamide dehydrogenase) (Glycine cleavage system L protein)

 

 

DPYD

 

Dihydropyrimidine dehydrogenase [NADP+] (DHPDHase) (DPD) (EC 1.3.1.2) (Dihydrouracil dehydrogenase) (Dihydrothymine dehydrogenase)

 

 

DUOX1 DUOX LNOX1 THOX1

 

Dual oxidase 1 (EC 1.6.3.1) (EC 1.11.1.-) (NADPH thyroid oxidase 1) (Large NOX 1) (Long NOX 1) (Thyroid oxidase 1)

 

 

DUOX2 LNOX2 THOX2

 

Dual oxidase 2 (EC 1.6.3.1) (EC 1.11.1.-) (NADPH oxidase/peroxidase DUOX2) (NADPH thyroid oxidase 2) (Large NOX 2) (Long NOX 2) (Thyroid oxidase 2) (NADH/NADPH thyroid oxidase p138-tox) (p138 thyroid oxidase)

 

 

ECSIT

 

Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial (Protein SITPEC)

 

 

EHHADH ECHD

 

Peroxisomal bifunctional enzyme (PBE) (PBFE) [Includes: Enoyl-CoA hydratase/3,2-trans-enoyl-CoA isomerase (EC 4.2.1.17) (EC 5.3.3.8); 3-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.35)]

 

 

ENOX1 PIG38

 

Ecto-NOX disulfide-thiol exchanger 1 (Constitutive Ecto-NOX) (cNOX) (Candidate growth-related and time keeping constitutive hydroquinone [NADH] oxidase) (cCNOX) (Cell proliferation-inducing gene 38 protein) [Includes: Hydroquinone [NADH] oxidase (EC 1.-.-.-); Protein disulfide-thiol oxidoreductase (EC 1.-.-.-)]

 

 

ENOX2 COVA1

 

Ecto-NOX disulfide-thiol exchanger 2 (Tumor-associated hydroquinone oxidase) (tNOX) (Cytosolic ovarian carcinoma antigen 1) (APK1 antigen) [Includes: Hydroquinone [NADH] oxidase (EC 1.-.-.-); Protein disulfide-thiol oxidoreductase (EC 1.-.-.-)]

 

 

ENPP3 PDNP3

 

Ectonucleotide pyrophosphatase/phosphodiesterase family member 3 (E-NPP 3) (Phosphodiesterase I/nucleotide pyrophosphatase 3) (Phosphodiesterase I beta) (PD-Ibeta) (CD antigen CD203c) [Includes: Alkaline phosphodiesterase I (EC 3.1.4.1); Nucleotide pyrophosphatase (NPPase) (EC 3.6.1.9)]

 

 

FAR1 MLSTD2 UNQ2423/PRO4981

 

Fatty acyl-CoA reductase 1 (EC 1.2.1.n2) (Male sterility domain-containing protein 2)

 

 

FAR2 MLSTD1

 

Fatty acyl-CoA reductase 2 (EC 1.2.1.n2) (Male sterility domain-containing protein 1)

 

 

FASN FAS

 

Fatty acid synthase (EC 2.3.1.85) [Includes: [Acyl-carrier-protein] S-acetyltransferase (EC 2.3.1.38); [Acyl-carrier-protein] S-malonyltransferase (EC 2.3.1.39); 3-oxoacyl-[acyl-carrier-protein] synthase (EC 2.3.1.41); 3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100); 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase (EC 4.2.1.61); Enoyl-[acyl-carrier-protein] reductase (EC 1.3.1.10); Oleoyl-[acyl-carrier-protein] hydrolase (EC 3.1.2.14)]

 

 

FDFT1

 

Squalene synthase (SQS) (SS) (EC 2.5.1.21) (Farnesyl-diphosphate farnesyltransferase) (FPP:FPP farnesyltransferase)

 

 

FDXR ADXR

 

NADPH:adrenodoxin oxidoreductase, mitochondrial (Adrenodoxin reductase) (AR) (EC 1.18.1.2) (Ferredoxin--NADP(+) reductase) (Ferredoxin reductase)

 

 

FMO1

 

Dimethylaniline monooxygenase [N-oxide-forming] 1 (EC 1.14.13.8) (Fetal hepatic flavin-containing monooxygenase 1) (FMO 1) (Dimethylaniline oxidase 1)

 

 

FMO2

 

Dimethylaniline monooxygenase [N-oxide-forming] 2 (EC 1.14.13.8) (Pulmonary flavin-containing monooxygenase 2) (FMO 2) (FMO 1B1) (Dimethylaniline oxidase 2)

 

 

FMO3

 

Dimethylaniline monooxygenase [N-oxide-forming] 3 (EC 1.14.13.8) (Hepatic flavin-containing monooxygenase 3) (FMO 3) (FMO form 2) (FMO II) (Dimethylaniline oxidase 3)

 

 

FMO4 FMO2

 

Dimethylaniline monooxygenase [N-oxide-forming] 4 (EC 1.14.13.8) (Hepatic flavin-containing monooxygenase 4) (FMO 4) (Dimethylaniline oxidase 4)

 

 

FMO5

 

Dimethylaniline monooxygenase [N-oxide-forming] 5 (EC 1.14.13.8) (Hepatic flavin-containing monooxygenase 5) (FMO 5) (Dimethylaniline oxidase 5)

 

 

FMO6P FMO6

 

Putative dimethylaniline monooxygenase [N-oxide-forming] 6 (EC 1.14.13.8) (Flavin-containing monooxygenase 6) (FMO 6) (Dimethylaniline oxidase 6)

 

 

FOXO4 AFX AFX1 MLLT7

 

Forkhead box protein O4 (Fork head domain transcription factor AFX1)

 

 

G6PD

 

Glucose-6-phosphate 1-dehydrogenase (G6PD) (EC 1.1.1.49)

 

 

GALE

 

UDP-glucose 4-epimerase (EC 5.1.3.2) (UDP-galactose 4-epimerase) (Galactowaldenase)

 

 

GAPDH GAPD CDABP0047 OK/SW-cl.12

 

Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) (EC 1.2.1.12)

 

 

GAPDHS GAPD2 GAPDH2 GAPDS HSD35 HSD-35

 

Glyceraldehyde-3-phosphate dehydrogenase, testis-specific (EC 1.2.1.12) (Spermatogenic glyceraldehyde-3-phosphate dehydrogenase) (Spermatogenic cell-specific glyceraldehyde 3-phosphate dehydrogenase 2) (GAPDH-2)

 

 

GLRX GRX

 

Glutaredoxin-1 (Thioltransferase-1) (TTase-1)

 

 

GLUD1 GLUD

 

Glutamate dehydrogenase 1, mitochondrial (GDH 1) (EC 1.4.1.3)

 

 

GLUD2 GLUDP1

 

Glutamate dehydrogenase 2, mitochondrial (GDH 2) (EC 1.4.1.3)

 

 

GLYR1 HIBDL NP60

 

Putative oxidoreductase GLYR1 (EC 1.-.-.-) (Glyoxylate reductase 1 homolog) (3-hydroxyisobutyrate dehydrogenase-like protein) (Nuclear protein NP60) (Nuclear protein of 60 kDa) (Cytokine-like nuclear factor N-PAC)

 

 

GMDS

 

GDP-mannose 4,6 dehydratase (EC 4.2.1.47) (GDP-D-mannose dehydratase) (GMD)

 

 

GMPR GMPR1

 

GMP reductase 1 (EC 1.7.1.7) (Guanosine 5'-monophosphate oxidoreductase 1) (Guanosine monophosphate reductase 1)

 

 

GMPR2

 

GMP reductase 2 (EC 1.7.1.7) (Guanosine 5'-monophosphate oxidoreductase 2) (Guanosine monophosphate reductase 2)

 

 

GPD1

 

Glycerol-3-phosphate dehydrogenase [NAD+], cytoplasmic (GPDH-C) (GPD-C) (EC 1.1.1.8)

 

 

GPD1L KIAA0089

 

Glycerol-3-phosphate dehydrogenase 1-like protein (GPD1-L) (EC 1.1.1.8)

 

 

GRHPR GLXR MSTP035

 

Glyoxylate reductase/hydroxypyruvate reductase (EC 1.1.1.79) (EC 1.1.1.81)

 

 

GSR GLUR GRD1

 

Glutathione reductase, mitochondrial (GRase) (GR) (EC 1.8.1.7)

 

 

H6PD GDH

 

GDH/6PGL endoplasmic bifunctional protein [Includes: Glucose 1-dehydrogenase (EC 1.1.1.47) (Hexose-6-phosphate dehydrogenase); 6-phosphogluconolactonase (6PGL) (EC 3.1.1.31)]

 

 

HAAO

 

3-hydroxyanthranilate 3,4-dioxygenase (EC 1.13.11.6) (3-hydroxyanthranilic acid dioxygenase) (HAD) (3-hydroxyanthranilate oxygenase) (3-HAO)

 

 

HADH HAD HADHSC SCHAD

 

Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial (HCDH) (EC 1.1.1.35) (Short-chain 3-hydroxyacyl-CoA dehydrogenase) (Medium and short-chain L-3-hydroxyacyl-coenzyme A dehydrogenase)

 

 

HADHA HADH

 

Trifunctional enzyme subunit alpha, mitochondrial (TP-alpha) (78 kDa gastrin-binding protein) [Includes: Long-chain enoyl-CoA hydratase (EC 4.2.1.17); Long chain 3-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.211)]

 

 

HIBADH

 

3-hydroxyisobutyrate dehydrogenase, mitochondrial (HIBADH) (EC 1.1.1.31)

 

 

HMGCR

 

3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA reductase) (EC 1.1.1.34)

 

 

HPGD PGDH1

 

15-hydroxyprostaglandin dehydrogenase [NAD+] (15-PGDH) (EC 1.1.1.141) (Prostaglandin dehydrogenase 1)

 

 

HSD11B1 HSD11 HSD11L

 

Corticosteroid 11-beta-dehydrogenase isozyme 1 (EC 1.1.1.146) (11-beta-hydroxysteroid dehydrogenase 1) (11-beta-HSD1) (11-DH)

 

 

HSD11B2 HSD11K

 

Corticosteroid 11-beta-dehydrogenase isozyme 2 (EC 1.1.1.-) (11-beta-hydroxysteroid dehydrogenase type 2) (11-beta-HSD2) (11-DH2) (NAD-dependent 11-beta-hydroxysteroid dehydrogenase)

 

 

HSD17B1 E17KSR EDH17B1 EDH17B2 EDHB17

 

Estradiol 17-beta-dehydrogenase 1 (EC 1.1.1.62) (17-beta-hydroxysteroid dehydrogenase type 1) (17-beta-HSD 1) (Placental 17-beta-hydroxysteroid dehydrogenase) (20 alpha-hydroxysteroid dehydrogenase) (20-alpha-HSD) (E2DH)

 

 

HSD17B10 ERAB HADH2 MRPP2 SCHAD XH98G2

 

3-hydroxyacyl-CoA dehydrogenase type-2 (EC 1.1.1.35) (3-hydroxyacyl-CoA dehydrogenase type II) (Type II HADH) (3-hydroxy-2-methylbutyryl-CoA dehydrogenase) (EC 1.1.1.178) (17-beta-hydroxysteroid dehydrogenase 10) (17-beta-HSD 10) (Mitochondrial ribonuclease P protein 2) (Mitochondrial RNase P protein 2) (Endoplasmic reticulum-associated amyloid beta-peptide-binding protein) (Short-chain type dehydrogenase/reductase XH98G2)

 

 

HSD17B11 DHRS8 PAN1B PSEC0029 UNQ207/PRO233

 

Estradiol 17-beta-dehydrogenase 11 (EC 1.1.1.62) (17-beta-hydroxysteroid dehydrogenase 11) (17-beta-HSD 11) (17betaHSD11) (17bHSD11) (17-beta-hydroxysteroid dehydrogenase XI) (17-beta-HSD XI) (17betaHSDXI) (Dehydrogenase/reductase SDR family member 8) (Retinal short-chain dehydrogenase/reductase 2) (retSDR2) (Cutaneous T-cell lymphoma-associated antigen HD-CL-03) (CTCL-associated antigen HD-CL-03)

 

 

HSD17B12

 

Estradiol 17-beta-dehydrogenase 12 (EC 1.1.1.62) (17-beta-hydroxysteroid dehydrogenase 12) (17-beta-HSD 12) (3-ketoacyl-CoA reductase) (KAR) (EC 1.3.1.-)

 

 

HSD17B14 DHRS10 SDR3 UNQ502/PRO474

 

17-beta-hydroxysteroid dehydrogenase 14 (17-beta-HSD 14) (EC 1.1.1.-) (Dehydrogenase/reductase SDR family member 10) (17-beta-hydroxysteroid dehydrogenase DHRS10) (Retinal short-chain dehydrogenase/reductase retSDR3)

 

 

HSD17B2 EDH17B2

 

Estradiol 17-beta-dehydrogenase 2 (EC 1.1.1.62) (Testosterone 17-beta-dehydrogenase) (EC 1.1.1.63) (Microsomal 17-beta-hydroxysteroid dehydrogenase) (17-beta-hydroxysteroid dehydrogenase type 2) (17-beta-HSD 2) (20 alpha-hydroxysteroid dehydrogenase) (20-alpha-HSD) (E2DH)

 

 

HSD17B4 EDH17B4

 

Peroxisomal multifunctional enzyme type 2 (MFE-2) (D-bifunctional protein) (DBP) (17-beta-hydroxysteroid dehydrogenase 4) (17-beta-HSD 4) [Includes: 3-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.35); 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholest-24-enoyl-CoA hydratase (EC 4.2.1.107)]

 

 

HSD17B6 RODH

 

17-beta-hydroxysteroid dehydrogenase type 6 (17-beta-HSD 6) (17-beta-HSD6) (EC 1.1.1.62) (EC 1.1.1.63) (EC 1.1.1.105) (Oxidative 3-alpha hydroxysteroid dehydrogenase) (3-alpha->beta-hydroxysteroid epimerase) (3-alpha->beta-HSE)

 

 

HSD17B7 UNQ2563/PRO6243

 

3-keto-steroid reductase (EC 1.1.1.270) (Estradiol 17-beta-dehydrogenase 7) (EC 1.1.1.62) (17-beta-hydroxysteroid dehydrogenase 7) (17-beta-HSD 7)

 

 

HSD17B8 FABGL HKE6 RING2

 

Estradiol 17-beta-dehydrogenase 8 (EC 1.1.1.62) (Testosterone 17-beta-dehydrogenase 8) (EC 1.1.1.63) (17-beta-hydroxysteroid dehydrogenase 8) (17-beta-HSD 8) (3-oxoacyl-[acyl-carrier-protein] reductase) (EC 1.1.1.-) (Protein Ke6) (Ke-6) (Really interesting new gene 2 protein)

 

 

HSD3B1 3BH HSDB3A

 

3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1 (3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I) (3-beta-HSD I) (Trophoblast antigen FDO161G) [Includes: 3-beta-hydroxy-Delta(5)-steroid dehydrogenase (EC 1.1.1.145) (3-beta-hydroxy-5-ene steroid dehydrogenase) (Progesterone reductase); Steroid Delta-isomerase (EC 5.3.3.1) (Delta-5-3-ketosteroid isomerase)]

 

 

HSD3B2 HSDB3B

 

3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2 (3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II) (3-beta-HSD II) [Includes: 3-beta-hydroxy-Delta(5)-steroid dehydrogenase (EC 1.1.1.145) (3-beta-hydroxy-5-ene steroid dehydrogenase) (Progesterone reductase); Steroid Delta-isomerase (EC 5.3.3.1) (Delta-5-3-ketosteroid isomerase)]

 

 

HSD3B7

 

3 beta-hydroxysteroid dehydrogenase type 7 (3 beta-hydroxysteroid dehydrogenase type VII) (3-beta-HSD VII) (3-beta-hydroxy-Delta(5)-C27 steroid oxidoreductase) (C(27) 3-beta-HSD) (EC 1.1.1.-) (Cholest-5-ene-3-beta,7-alpha-diol 3-beta-dehydrogenase) (EC 1.1.1.181)

 

 

HTATIP2 CC3 TIP30

 

Oxidoreductase HTATIP2 (EC 1.1.1.-) (HIV-1 TAT-interactive protein 2) (30 kDa HIV-1 TAT-interacting protein)

 

 

IDH1 PICD

 

Isocitrate dehydrogenase [NADP] cytoplasmic (IDH) (EC 1.1.1.42) (Cytosolic NADP-isocitrate dehydrogenase) (Oxalosuccinate decarboxylase) (NADP(+)-specific ICDH) (IDP)

 

 

IDH2

 

Isocitrate dehydrogenase [NADP], mitochondrial (IDH) (EC 1.1.1.42) (Oxalosuccinate decarboxylase) (NADP(+)-specific ICDH) (IDP) (ICD-M)

 

 

IDH3A

 

Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial (EC 1.1.1.41) (Isocitric dehydrogenase subunit alpha) (NAD(+)-specific ICDH subunit alpha)

 

 

IDH3B

 

Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial (EC 1.1.1.41) (Isocitric dehydrogenase subunit beta) (NAD(+)-specific ICDH subunit beta)

 

 

IDH3G

 

Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial (EC 1.1.1.41) (Isocitric dehydrogenase subunit gamma) (NAD(+)-specific ICDH subunit gamma)

 

 

IMPDH1 IMPD1

 

Inosine-5'-monophosphate dehydrogenase 1 (IMP dehydrogenase 1) (IMPDH 1) (IMPD 1) (EC 1.1.1.205) (IMPDH-I)

 

 

IMPDH2 IMPD2

 

Inosine-5'-monophosphate dehydrogenase 2 (IMP dehydrogenase 2) (IMPDH 2) (IMPD 2) (EC 1.1.1.205) (IMPDH-II)

 

 

ISYNA1 INO1

 

Inositol-3-phosphate synthase 1 (IPS 1) (EC 5.5.1.4) (Myo-inositol-1-phosphate synthase) (MI-1-P synthase) (MIP synthase) (hIPS) (Myo-inositol 1-phosphate synthase A1) (hINO1)

 

 

ITGB1BP3 NRK2

 

Nicotinamide riboside kinase 2 (NmR-K 2) (NRK 2) (EC 2.7.1.22) (Ribosylnicotinamide kinase 2) (RNK 2) (Nicotinic acid riboside kinase 2) (EC 2.7.1.n4) (Ribosylnicotinic acid kinase 2) (Integrin beta-1-binding protein 3) (Muscle integrin-binding protein) (MIBP)

 

 

IYD C6orf71 DEHAL1

 

Iodotyrosine dehalogenase 1 (IYD-1) (EC 1.-.-.-)

 

 

KDSR FVT1

 

3-ketodihydrosphingosine reductase (KDS reductase) (EC 1.1.1.102) (3-dehydrosphinganine reductase) (Follicular variant translocation protein 1) (FVT-1)

 

 

KMO

 

Kynurenine 3-monooxygenase (EC 1.14.13.9) (Kynurenine 3-hydroxylase)

 

 

KYNU

 

Kynureninase (EC 3.7.1.3) (L-kynurenine hydrolase)

 

 

LDHA PIG19

 

L-lactate dehydrogenase A chain (LDH-A) (EC 1.1.1.27) (LDH muscle subunit) (LDH-M) (Renal carcinoma antigen NY-REN-59) (Cell proliferation-inducing gene 19 protein)

 

 

LDHAL6A LDHL2

 

L-lactate dehydrogenase A-like 6A (EC 1.1.1.27)

 

 

LDHAL6B LDHAL6 LDHL

 

L-lactate dehydrogenase A-like 6B (EC 1.1.1.27)

 

 

LDHB

 

L-lactate dehydrogenase B chain (LDH-B) (EC 1.1.1.27) (LDH heart subunit) (LDH-H) (Renal carcinoma antigen NY-REN-46)

 

 

LDHC

 

L-lactate dehydrogenase C chain (LDH-C) (EC 1.1.1.27) (LDH testis subunit) (LDH-X) (Cancer/testis antigen 32) (CT32)

 

 

MDH2

 

Malate dehydrogenase, mitochondrial (EC 1.1.1.37)

 

 

ME1

 

NADP-dependent malic enzyme (NADP-ME) (EC 1.1.1.40) (Malic enzyme 1)

 

 

ME2

 

NAD-dependent malic enzyme, mitochondrial (NAD-ME) (EC 1.1.1.38) (Malic enzyme 2)

 

 

ME3

 

NADP-dependent malic enzyme, mitochondrial (NADP-ME) (EC 1.1.1.40) (Malic enzyme 3)

 

 

MECR NBRF1 CGI-63

 

Trans-2-enoyl-CoA reductase, mitochondrial (EC 1.3.1.38) (Nuclear receptor-binding factor 1) (NRBF-1) (HsNrbf-1)

 

 

MOSC2

 

MOSC domain-containing protein 2, mitochondrial (EC 1.-.-.-)

 

 

MT-ND1 MTND1 NADH1 ND1

 

NADH-ubiquinone oxidoreductase chain 1 (EC 1.6.5.3) (NADH dehydrogenase subunit 1)

 

 

MT-ND2 MTND2 NADH2 ND2

 

NADH-ubiquinone oxidoreductase chain 2 (EC 1.6.5.3) (NADH dehydrogenase subunit 2)

 

 

MT-ND3 MTND3 NADH3 ND3

 

NADH-ubiquinone oxidoreductase chain 3 (EC 1.6.5.3) (NADH dehydrogenase subunit 3)

 

 

MT-ND4 MTND4 NADH4 ND4

 

NADH-ubiquinone oxidoreductase chain 4 (EC 1.6.5.3) (NADH dehydrogenase subunit 4)

 

 

MT-ND4L MTND4L NADH4L ND4L

 

NADH-ubiquinone oxidoreductase chain 4L (EC 1.6.5.3) (NADH dehydrogenase subunit 4L)

 

 

MT-ND5 MTND5 NADH5 ND5

 

NADH-ubiquinone oxidoreductase chain 5 (EC 1.6.5.3) (NADH dehydrogenase subunit 5)

 

 

MT-ND6 MTND6 NADH6 ND6

 

NADH-ubiquinone oxidoreductase chain 6 (EC 1.6.5.3) (NADH dehydrogenase subunit 6)

 

 

MTHFD1 MTHFC MTHFD

 

C-1-tetrahydrofolate synthase, cytoplasmic (C1-THF synthase) [Includes: Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9); Formyltetrahydrofolate synthetase (EC 6.3.4.3)]

 

 

MTHFD2 NMDMC

 

Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial [Includes: NAD-dependent methylenetetrahydrofolate dehydrogenase (EC 1.5.1.15); Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)]

 

 

MTHFD2L

 

Probable bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2 (NADP-dependent methylenetetrahydrofolate dehydrogenase 2-like protein) [Includes: NAD-dependent methylenetetrahydrofolate dehydrogenase (EC 1.5.1.15); Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)]

 

 

MTHFR

 

Methylenetetrahydrofolate reductase (EC 1.5.1.20)

 

 

MTRR

 

Methionine synthase reductase (MSR) (EC 1.16.1.8)

 

 

NADK

 

NAD kinase (EC 2.7.1.23) (Poly(P)/ATP NAD kinase)

 

 

NADSYN1

 

Glutamine-dependent NAD(+) synthetase (EC 6.3.5.1) (NAD(+) synthase [glutamine-hydrolyzing]) (NAD(+) synthetase)

 

 

NAMPT PBEF PBEF1

 

Nicotinamide phosphoribosyltransferase (NAmPRTase) (Nampt) (EC 2.4.2.12) (Pre-B-cell colony-enhancing factor 1) (Pre-B cell-enhancing factor) (Visfatin)

 

 

NAPRT1 FHIP

 

Nicotinate phosphoribosyltransferase (NAPRTase) (EC 2.4.2.11) (Nicotinate phosphoribosyltransferase domain-containing protein 1) (FHA-HIT-interacting protein)

 

 

NCF1 NOXO2 SH3PXD1A

 

Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K) (47 kDa autosomal chronic granulomatous disease protein) (Nox-organizing protein 2) (Nox organizer 2) (SH3 and PX domain-containing protein 1A)

 

 

NCF1B SH3PXD1B

 

Putative neutrophil cytosol factor 1B (NCF-1B) (Putative SH3 and PX domain-containing protein 1B)

 

 

NCF1C SH3PXD1C

 

Putative neutrophil cytosol factor 1C (NCF-1C) (Putative SH3 and PX domain-containing protein 1C)

 

 

NCF2 NOXA2 P67PHOX

 

Neutrophil cytosol factor 2 (NCF-2) (Neutrophil NADPH oxidase factor 2) (NADPH oxidase activator 2) (67 kDa neutrophil oxidase factor) (p67-phox)

 

 

NCF4 SH3PXD4

 

Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox) (SH3 and PX domain-containing protein 4)

 

 

NDOR1 NR1

 

NADPH-dependent diflavin oxidoreductase 1 (EC 1.6.-.-) (Novel reductase 1) (NADPH-dependent FMN and FAD-containing oxidoreductase)

 

 

NDUFA1

 

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 (NADH-ubiquinone oxidoreductase MWFE subunit) (Complex I-MWFE) (CI-MWFE)

 

 

NDUFA10

 

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial (NADH-ubiquinone oxidoreductase 42 kDa subunit) (Complex I-42kD) (CI-42kD)

 

 

NDUFA11

 

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 (NADH-ubiquinone oxidoreductase subunit B14.7) (Complex I-B14.7) (CI-B14.7)

 

 

NDUFA12 DAP13

 

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 (NADH-ubiquinone oxidoreductase subunit B17.2) (Complex I-B17.2) (CI-B17.2) (CIB17.2) (13 kDa differentiation-associated protein)

 

 

NDUFA13 GRIM19 CGI-39 CDA016

 

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 (NADH-ubiquinone oxidoreductase B16.6 subunit) (Complex I-B16.6) (CI-B16.6) (Gene associated with retinoic and interferon-induced mortality 19 protein) (Gene associated with retinoic and IFN-induced mortality 19 protein) (GRIM-19) (Cell death regulatory protein GRIM-19)

 

 

NDUFA2

 

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 (NADH-ubiquinone oxidoreductase B8 subunit) (Complex I-B8) (CI-B8)

 

 

NDUFA3

 

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 (NADH-ubiquinone oxidoreductase B9 subunit) (Complex I-B9) (CI-B9)

 

 

NDUFA4

 

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4 (NADH-ubiquinone oxidoreductase MLRQ subunit) (Complex I-MLRQ) (CI-MLRQ)

 

 

NDUFA5

 

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 (NADH-ubiquinone oxidoreductase 13 kDa-B subunit) (Complex I-13kD-B) (CI-13kD-B) (Complex I subunit B13)

 

 

NDUFA6 LYRM6 NADHB14

 

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 (NADH-ubiquinone oxidoreductase B14 subunit) (Complex I-B14) (CI-B14) (LYR motif-containing protein 6)

 

 

NDUFA7

 

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 (NADH-ubiquinone oxidoreductase subunit B14.5a) (Complex I-B14.5a) (CI-B14.5a)

 

 

NDUFA8

 

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 (NADH-ubiquinone oxidoreductase 19 kDa subunit) (Complex I-19kD) (CI-19kD) (Complex I-PGIV) (CI-PGIV)

 

 

NDUFA9 NDUFS2L

 

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial (NADH-ubiquinone oxidoreductase 39 kDa subunit) (Complex I-39kD) (CI-39kD)

 

 

NDUFAB1

 

Acyl carrier protein, mitochondrial (ACP) (NADH-ubiquinone oxidoreductase 9.6 kDa subunit) (CI-SDAP)

 

 

NDUFAF1 CIA30 CGI-65

 

Complex I intermediate-associated protein 30, mitochondrial (NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 1)

 

 

NDUFAF3 C3orf60

 

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3

 

 

NDUFAF4 C6orf66 HRPAP20 HSPC125 My013

 

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4 (Hormone-regulated proliferation-associated protein of 20 kDa)

 

 

NDUFB1

 

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 (NADH-ubiquinone oxidoreductase MNLL subunit) (Complex I-MNLL) (CI-MNLL)

 

 

NDUFB10

 

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 (NADH-ubiquinone oxidoreductase PDSW subunit) (Complex I-PDSW) (CI-PDSW)

 

 

NDUFB11 UNQ111/PRO1064

 

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial (NADH-ubiquinone oxidoreductase ESSS subunit) (Complex I-ESSS) (CI-ESSS) (Neuronal protein 17.3) (Np17.3) (p17.3)

 

 

NDUFB2

 

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial (NADH-ubiquinone oxidoreductase AGGG subunit) (Complex I-AGGG) (CI-AGGG)

 

 

NDUFB3

 

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 (NADH-ubiquinone oxidoreductase B12 subunit) (Complex I-B12) (CI-B12)

 

 

NDUFB4

 

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 (NADH-ubiquinone oxidoreductase B15 subunit) (Complex I-B15) (CI-B15)

 

 

NDUFB5

 

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial (NADH-ubiquinone oxidoreductase SGDH subunit) (Complex I-SGDH) (CI-SGDH)

 

 

NDUFB6

 

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 (NADH-ubiquinone oxidoreductase B17 subunit) (Complex I-B17) (CI-B17)

 

 

NDUFB7

 

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 (NADH-ubiquinone oxidoreductase B18 subunit) (Complex I-B18) (CI-B18) (Cell adhesion protein SQM1)

 

 

NDUFB8

 

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial (NADH-ubiquinone oxidoreductase ASHI subunit) (Complex I-ASHI) (CI-ASHI)

 

 

NDUFB9 LYRM3 UQOR22

 

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 (NADH-ubiquinone oxidoreductase B22 subunit) (Complex I-B22) (CI-B22) (LYR motif-containing protein 3)

 

 

NDUFC1

 

NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial (NADH-ubiquinone oxidoreductase KFYI subunit) (Complex I-KFYI) (CI-KFYI)

 

 

NDUFC2 HLC1

 

NADH dehydrogenase [ubiquinone] 1 subunit C2 (NADH-ubiquinone oxidoreductase subunit B14.5b) (Complex I-B14.5b) (CI-B14.5b) (Human lung cancer oncogene 1 protein) (HLC-1)

 

 

NDUFS1

 

NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial (EC 1.6.5.3) (EC 1.6.99.3) (Complex I-75kD) (CI-75kD)

 

 

NDUFS2

 

NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial (EC 1.6.5.3) (EC 1.6.99.3) (NADH-ubiquinone oxidoreductase 49 kDa subunit) (Complex I-49kD) (CI-49kD)

 

 

NDUFS3

 

NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial (EC 1.6.5.3) (EC 1.6.99.3) (NADH-ubiquinone oxidoreductase 30 kDa subunit) (Complex I-30kD) (CI-30kD)

 

 

NDUFS4

 

NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial (NADH-ubiquinone oxidoreductase 18 kDa subunit) (Complex I-18 kDa) (CI-18 kDa) (Complex I-AQDQ) (CI-AQDQ)

 

 

NDUFS5

 

NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 (NADH-ubiquinone oxidoreductase 15 kDa subunit) (Complex I-15 kDa) (CI-15 kDa)

 

 

NDUFS6

 

NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial (NADH-ubiquinone oxidoreductase 13 kDa-A subunit) (Complex I-13kD-A) (CI-13kD-A)

 

 

NDUFS7

 

NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial (EC 1.6.5.3) (EC 1.6.99.3) (NADH-ubiquinone oxidoreductase 20 kDa subunit) (Complex I-20kD) (CI-20kD) (PSST subunit)

 

 

NDUFS8

 

NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial (EC 1.6.5.3) (EC 1.6.99.3) (NADH-ubiquinone oxidoreductase 23 kDa subunit) (Complex I-23kD) (CI-23kD) (TYKY subunit)

 

 

NDUFV1 UQOR1

 

NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial (EC 1.6.5.3) (EC 1.6.99.3) (NADH-ubiquinone oxidoreductase 51 kDa subunit) (Complex I-51kD) (CI-51kD) (NADH dehydrogenase flavoprotein 1)

 

 

NDUFV2

 

NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial (EC 1.6.5.3) (EC 1.6.99.3) (NADH-ubiquinone oxidoreductase 24 kDa subunit)

 

 

NDUFV3

 

NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial (NADH-ubiquinone oxidoreductase 9 kDa subunit) (Complex I-9kD) (CI-9kD) (Renal carcinoma antigen NY-REN-4)

 

 

NMNAT1 NMNAT

 

Nicotinamide mononucleotide adenylyltransferase 1 (NMN adenylyltransferase 1) (EC 2.7.7.1) (Nicotinate-nucleotide adenylyltransferase 1) (NaMN adenylyltransferase 1) (EC 2.7.7.18)

 

 

NMNAT2 C1orf15 KIAA0479

 

Nicotinamide mononucleotide adenylyltransferase 2 (NMN adenylyltransferase 2) (EC 2.7.7.1) (Nicotinate-nucleotide adenylyltransferase 2) (NaMN adenylyltransferase 2) (EC 2.7.7.18)

 

 

NMNAT3 FKSG76

 

Nicotinamide mononucleotide adenylyltransferase 3 (NMN adenylyltransferase 3) (Pyridine nucleotide adenylyltransferase 3) (PNAT-3) (EC 2.7.7.1) (Nicotinate-nucleotide adenylyltransferase 3) (NaMN adenylyltransferase 3) (EC 2.7.7.18)

 

 

NMRAL1 HSCARG

 

NmrA-like family domain-containing protein 1

 

 

NNT

 

NAD(P) transhydrogenase, mitochondrial (EC 1.6.1.2) (Nicotinamide nucleotide transhydrogenase) (Pyridine nucleotide transhydrogenase)

 

 

NOS1

 

Nitric oxide synthase, brain (EC 1.14.13.39) (bNOS) (NOS type I) (Neuronal NOS) (N-NOS) (nNOS) (Constitutive NOS) (NC-NOS)

 

 

NOS2 NOS2A

 

Nitric oxide synthase, inducible (EC 1.14.13.39) (Inducible NO synthase) (Inducible NOS) (iNOS) (NOS type II) (Hepatocyte NOS) (HEP-NOS)

 

 

NOS3

 

Nitric oxide synthase, endothelial (EC 1.14.13.39) (Endothelial NOS) (eNOS) (EC-NOS) (NOS type III) (NOSIII) (Constitutive NOS) (cNOS)

 

 

NOX1 MOX1 NOH1

 

NADPH oxidase 1 (NOX-1) (EC 1.-.-.-) (NOH-1) (NADH/NADPH mitogenic oxidase subunit P65-MOX) (Mitogenic oxidase 1) (MOX-1)

 

 

NOX3 MOX2

 

NADPH oxidase 3 (EC 1.6.3.-) (gp91phox homolog 3) (GP91-3) (Mitogenic oxidase 2) (MOX-2)

 

 

NOX4 RENOX

 

NADPH oxidase 4 (EC 1.6.3.-) (Kidney superoxide-producing NADPH oxidase) (Kidney oxidase-1) (KOX-1) (Renal NAD(P)H-oxidase)

 

 

NOX5

 

NADPH oxidase 5 (EC 1.6.3.-)

 

 

NOXA1 P51NOX

 

NADPH oxidase activator 1 (NOX activator 1) (P67phox-like factor) (p51-nox) (NCF2-like protein) (Antigen NY-CO-31)

 

 

NQO1 DIA4 NMOR1

 

NAD(P)H dehydrogenase [quinone] 1 (EC 1.6.5.2) (Quinone reductase 1) (QR1) (NAD(P)H:quinone oxidoreductase 1) (DT-diaphorase) (DTD) (Azoreductase) (Phylloquinone reductase) (Menadione reductase)

 

 

NQO2 NMOR2

 

Ribosyldihydronicotinamide dehydrogenase [quinone] (EC 1.10.99.2) (NRH dehydrogenase [quinone] 2) (NRH:quinone oxidoreductase 2) (Quinone reductase 2) (QR2)

 

 

NRK1 C9orf95

 

Nicotinamide riboside kinase 1 (NmR-K 1) (NRK 1) (EC 2.7.1.22) (Ribosylnicotinamide kinase 1) (RNK 1) (Nicotinic acid riboside kinase 1) (EC 2.7.1.n4) (Ribosylnicotinic acid kinase 1)

 

 

NSDHL H105E3

 

Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating (EC 1.1.1.170) (Protein H105e3)

 

 

NUDT12

 

Peroxisomal NADH pyrophosphatase NUDT12 (EC 3.6.1.22) (Nucleoside diphosphate-linked moiety X motif 12) (Nudix motif 12)

 

 

NUDT7

 

Peroxisomal coenzyme A diphosphatase NUDT7 (EC 3.6.1.-) (Nucleoside diphosphate-linked moiety X motif 7) (Nudix motif 7)

 

 

NXN NRX

 

Nucleoredoxin (EC 1.8.1.8)

 

 

P2Y1  P2RY1

 

Purinergic receptor p2y, g protein-coupled, 1; p2ry1

 

 

PARP1 ADPRT PPOL

 

Poly [ADP-ribose] polymerase 1 (PARP-1) (EC 2.4.2.30) (NAD(+) ADP-ribosyltransferase 1) (ADPRT 1) (Poly[ADP-ribose] synthase 1)

 

 

PARP10

 

Poly [ADP-ribose] polymerase 10 (PARP-10) (EC 2.4.2.30)

 

 

PARP11 C12orf6

 

Poly [ADP-ribose] polymerase 11 (PARP-11) (EC 2.4.2.30)

 

 

PARP12 ZC3HDC1

 

Poly [ADP-ribose] polymerase 12 (PARP-12) (EC 2.4.2.30) (Zinc finger CCCH domain-containing protein 1)

 

 

PARP14 BAL2 KIAA1268

 

Poly [ADP-ribose] polymerase 14 (PARP-14) (EC 2.4.2.30) (B aggressive lymphoma protein 2)

 

 

PARP15 BAL3

 

Poly [ADP-ribose] polymerase 15 (PARP-15) (EC 2.4.2.30) (B-aggressive lymphoma protein 3)

 

 

PARP16 C15orf30

 

Poly [ADP-ribose] polymerase 16 (PARP-16) (EC 2.4.2.30)

 

 

PARP2 ADPRT2 ADPRTL2

 

Poly [ADP-ribose] polymerase 2 (PARP-2) (hPARP-2) (EC 2.4.2.30) (NAD(+) ADP-ribosyltransferase 2) (ADPRT-2) (Poly[ADP-ribose] synthase 2) (pADPRT-2)

 

 

PARP3 ADPRT3 ADPRTL3

 

Poly [ADP-ribose] polymerase 3 (PARP-3) (hPARP-3) (EC 2.4.2.30) (NAD(+) ADP-ribosyltransferase 3) (ADPRT-3) (Poly[ADP-ribose] synthase 3) (pADPRT-3) (IRT1)

 

 

PARP4 ADPRTL1 KIAA0177 PARPL

 

Poly [ADP-ribose] polymerase 4 (PARP-4) (EC 2.4.2.30) (Vault poly(ADP-ribose) polymerase) (VPARP) (193 kDa vault protein) (PARP-related/IalphaI-related H5/proline-rich) (PH5P)

 

 

PARP6

 

Poly [ADP-ribose] polymerase 6 (PARP-6) (EC 2.4.2.30)

 

 

PARP8

 

Poly [ADP-ribose] polymerase 8 (PARP-8) (EC 2.4.2.30)

 

 

PARP9 BAL

 

Poly [ADP-ribose] polymerase 9 (PARP-9) (EC 2.4.2.30) (B aggressive lymphoma protein)

 

 

PECR PRO1004

 

Peroxisomal trans-2-enoyl-CoA reductase (TERP) (EC 1.3.1.38) (HPDHase) (pVI-ARL) (2,4-dienoyl-CoA reductase-related protein) (DCR-RP)

 

 

PGD PGDH

 

6-phosphogluconate dehydrogenase, decarboxylating (EC 1.1.1.44)

 

 

PHGDH PGDH3

 

D-3-phosphoglycerate dehydrogenase (3-PGDH) (EC 1.1.1.95)

 

 

POR CYPOR

 

NADPH--cytochrome P450 reductase (CPR) (P450R) (EC 1.6.2.4)

 

 

PTGR1 LTB4DH

 

Prostaglandin reductase 1 (PRG-1) (EC 1.3.1.-) (NADP-dependent leukotriene B4 12-hydroxydehydrogenase) (EC 1.3.1.74) (15-oxoprostaglandin 13-reductase) (EC 1.3.1.48)

 

 

PTGR2 ZADH1

 

Prostaglandin reductase 2 (PRG-2) (EC 1.3.1.48) (15-oxoprostaglandin 13-reductase) (Zinc-binding alcohol dehydrogenase domain-containing protein 1)

 

 

PYCR1

 

Pyrroline-5-carboxylate reductase 1, mitochondrial (P5C reductase 1) (P5CR 1) (EC 1.5.1.2)

 

 

PYCR2

 

Pyrroline-5-carboxylate reductase 2 (P5C reductase 2) (P5CR 2) (EC 1.5.1.2)

 

 

PYCRL

 

Pyrroline-5-carboxylate reductase 3 (P5C reductase 3) (P5CR 3) (EC 1.5.1.2) (Pyrroline-5-carboxylate reductase-like protein)

 

 

QDPR DHPR

 

Dihydropteridine reductase (EC 1.5.1.34) (HDHPR) (Quinoid dihydropteridine reductase)

 

 

QPRT

 

Nicotinate-nucleotide pyrophosphorylase [carboxylating] (EC 2.4.2.19) (Quinolinate phosphoribosyltransferase [decarboxylating]) (QAPRTase) (QPRTase)

 

 

RAC2

 

Ras-related C3 botulinum toxin substrate 2 (p21-Rac2) (Small G protein) (GX)

 

 

RDH10 UNQ9375/PRO34191

 

Retinol dehydrogenase 10 (EC 1.1.1.300)

 

 

RDH11 ARSDR1 PSDR1 CGI-82

 

Retinol dehydrogenase 11 (EC 1.1.1.-) (Retinal reductase 1) (RalR1) (Prostate short-chain dehydrogenase/reductase 1) (Androgen-regulated short-chain dehydrogenase/reductase 1) (HCV core-binding protein HCBP12)

 

 

RDH12

 

Retinol dehydrogenase 12 (EC 1.1.1.-) (All-trans and 9-cis retinol dehydrogenase)

 

 

RDH14 PAN2 UNQ529/PRO1072

 

Retinol dehydrogenase 14 (EC 1.1.1.-) (Alcohol dehydrogenase PAN2)

 

 

RDH16 RODH4

 

Retinol dehydrogenase 16 (EC 1.1.-.-) (Sterol/retinol dehydrogenase) (Microsomal NAD+-dependent retinol dehydrogenase 4) (RoDH-4)

 

 

RDH5 RDH1

 

11-cis retinol dehydrogenase (11-cis RDH) (EC 1.1.1.105)

 

 

RDH8 PRRDH

 

Retinol dehydrogenase 8 (EC 1.1.1.300) (Photoreceptor outer segment all-trans retinol dehydrogenase)

 

 

RETSAT UNQ439/PRO872

 

All-trans-retinol 13,14-reductase (EC 1.3.99.23) (All-trans-13,14-dihydroretinol saturase) (RetSat)

 

 

RRP8 KIAA0409 NML hucep-1

 

Ribosomal RNA-processing protein 8 (EC 2.1.1.-) (Nucleomethylin) (Cerebral protein 1)

 

 

SC4MOL DESP4 ERG25

 

C-4 methylsterol oxidase (EC 1.14.13.72) (Methylsterol monooxygenase)

 

 

SC5DL

 

Lathosterol oxidase (EC 1.14.21.6) (Lathosterol 5-desaturase) (Delta(7)-sterol 5-desaturase) (C-5 sterol desaturase) (Sterol-C5-desaturase)

 

 

SCCPDH CGI-49

 

Probable saccharopine dehydrogenase (EC 1.5.1.9)

 

 

SDR16C5 RDHE2

 

Epidermal retinol dehydrogenase 2 (RDH-E2) (EPHD-2) (EC 1.1.1.105) (Retinal short-chain dehydrogenase reductase 2) (retSDR2) (Short-chain dehydrogenase/reductase family 16C member 5)

 

 

SDR9C7 RDHS SDRO

 

Short-chain dehydrogenase/reductase family 9C member 7 (EC 1.1.1.-) (Orphan short-chain dehydrogenase/reductase) (SDR-O) (RDH-S)

 

 

SIRT1 SIR2L1

 

NAD-dependent deacetylase sirtuin-1 (hSIRT1) (EC 3.5.1.-) (SIR2-like protein 1) (hSIR2)

 

 

SIRT2 SIR2L SIR2L2

 

NAD-dependent deacetylase sirtuin-2 (EC 3.5.1.-) (SIR2-like protein 2)

 

 

SIRT3 SIR2L3

 

NAD-dependent deacetylase sirtuin-3, mitochondrial (hSIRT3) (EC 3.5.1.-) (SIR2-like protein 3)

 

 

SIRT4 SIR2L4

 

NAD-dependent ADP-ribosyltransferase sirtuin-4 (EC 2.4.2.-) (SIR2-like protein 4)

 

 

SIRT5 SIR2L5

 

NAD-dependent deacetylase sirtuin-5 (EC 3.5.1.-) (SIR2-like protein 5)

 

 

SIRT6 SIR2L6

 

NAD-dependent deacetylase sirtuin-6 (EC 3.5.1.-) (SIR2-like protein 6)

 

 

SIRT7 SIR2L7

 

NAD-dependent deacetylase sirtuin-7 (EC 3.5.1.-) (SIR2-like protein 7)

 

 

SLC25A1 SLC20A3

 

Tricarboxylate transport protein, mitochondrial (Citrate transport protein) (CTP) (Tricarboxylate carrier protein) (Solute carrier family 25 member 1)

 

 

SORD

 

Sorbitol dehydrogenase (EC 1.1.1.14) (L-iditol 2-dehydrogenase)

 

 

SPR

 

Sepiapterin reductase (SPR) (EC 1.1.1.153)

 

 

STEAP1 PRSS24 STEAP

 

Metalloreductase STEAP1 (EC 1.16.1.-) (Six-transmembrane epithelial antigen of prostate 1)

 

 

STEAP2 PCANAP1 STAMP1 UNQ6507/PRO23203

 

Metalloreductase STEAP2 (EC 1.16.1.-) (Six-transmembrane epithelial antigen of prostate 2) (SixTransMembrane protein of prostate 1) (Prostate cancer-associated protein 1) (Protein upregulated in metastatic prostate cancer) (PUMPCn)

 

 

STEAP3 TSAP6

 

Metalloreductase STEAP3 (EC 1.16.1.-) (Six-transmembrane epithelial antigen of prostate 3) (Tumor suppressor-activated pathway protein 6) (hTSAP6) (pHyde) (hpHyde) (Dudulin-2)

 

 

STEAP4 STAMP2 TNFAIP9

 

Metalloreductase STEAP4 (EC 1.16.1.-) (Six-transmembrane epithelial antigen of prostate 4) (SixTransMembrane protein of prostate 2) (Tumor necrosis factor, alpha-induced protein 9)

 

 

SUV39H1 KMT1A SUV39H

 

Histone-lysine N-methyltransferase SUV39H1 (EC 2.1.1.43) (Suppressor of variegation 3-9 homolog 1) (Su(var)3-9 homolog 1) (Position-effect variegation 3-9 homolog) (Histone H3-K9 methyltransferase 1) (H3-K9-HMTase 1) (Lysine N-methyltransferase 1A)

 

 

TDH

 

Inactive L-threonine 3-dehydrogenase, mitochondrial

 

 

TGDS

 

dTDP-D-glucose 4,6-dehydratase (EC 4.2.1.46)

 

 

TIPARP PARP7

 

TCDD-inducible poly [ADP-ribose] polymerase (EC 2.4.2.30) (Poly [ADP-ribose] polymerase 7) (PARP-7)

 

 

TM7SF2 ANG1

 

Delta(14)-sterol reductase (Delta-14-SR) (EC 1.3.1.70) (C-14 sterol reductase) (Sterol C14-reductase) (Transmembrane 7 superfamily member 2) (Another new gene 1 protein) (Putative sterol reductase SR-1)

 

 

TNKS PARP5A PARPL TIN1 TINF1 TNKS1

 

Tankyrase-1 (TANK1) (EC 2.4.2.30) (Tankyrase I) (TNKS-1) (TRF1-interacting ankyrin-related ADP-ribose polymerase) (Poly [ADP-ribose] polymerase 5A)

 

 

TNKS2 PARP5B TANK2 TNKL

 

Tankyrase-2 (TANK2) (EC 2.4.2.30) (Tankyrase II) (TNKS-2) (TRF1-interacting ankyrin-related ADP-ribose polymerase 2) (Tankyrase-like protein) (Tankyrase-related protein) (Poly [ADP-ribose] polymerase 5B)

 

 

TP53I3 PIG3

 

Quinone oxidoreductase PIG3 (EC 1.-.-.-) (Tumor protein p53-inducible protein 3) (p53-induced gene 3 protein)

 

 

TRPM2 EREG1 KNP3 LTRPC2 TRPC7

 

Transient receptor potential cation channel subfamily M member 2 (EC 3.6.1.13) (Long transient receptor potential channel 2) (LTrpC-2) (LTrpC2) (Transient receptor potential channel 7) (TrpC7) (Estrogen-responsive element-associated gene 1 protein)

 

 

TRPT1

 

tRNA 2'-phosphotransferase 1 (EC 2.7.1.160)

 

 

TSTA3 SDR4E1

 

GDP-L-fucose synthase (EC 1.1.1.271) (Protein FX) (Red cell NADP(H)-binding protein) (GDP-4-keto-6-deoxy-D-mannose-3,5-epimerase-4-reductase) (Short-chain dehydrogenase/reductase family 4E member 1)

 

 

TXNDC2 SPTRX SPTRX1

 

Thioredoxin domain-containing protein 2 (Spermatid-specific thioredoxin-1) (Sptrx-1)

 

 

TXNRD1 GRIM12 KDRF

 

Thioredoxin reductase 1, cytoplasmic (TR) (EC 1.8.1.9) (Thioredoxin reductase TR1) (KM-102-derived reductase-like factor) (Gene associated with retinoic and interferon-induced mortality 12 protein) (Gene associated with retinoic and IFN-induced mortality 12 protein) (GRIM-12)

 

 

TXNRD2 KIAA1652 TRXR2

 

Thioredoxin reductase 2, mitochondrial (EC 1.8.1.9) (Thioredoxin reductase TR3) (TR-beta) (Selenoprotein Z) (SelZ)

 

 

TXNRD3 TGR TRXR3

 

Thioredoxin reductase 3 (EC 1.8.1.9) (Thioredoxin reductase TR2) (Thioredoxin and glutathione reductase) (Fragment)

 

 

UGDH

 

UDP-glucose 6-dehydrogenase (UDP-Glc dehydrogenase) (UDP-GlcDH) (UDPGDH) (EC 1.1.1.22)

 

 

UROC1

 

Urocanate hydratase (Urocanase) (EC 4.2.1.49) (Imidazolonepropionate hydrolase)

 

 

UXS1 UNQ2538/PRO6079

 

UDP-glucuronic acid decarboxylase 1 (EC 4.1.1.35) (UDP-glucuronate decarboxylase 1) (UXS-1) (UGD)

 

 

XDH XDHA

 

Xanthine dehydrogenase/oxidase [Includes: Xanthine dehydrogenase (XD) (EC 1.17.1.4); Xanthine oxidase (XO) (EC 1.17.3.2) (Xanthine oxidoreductase)]

 

 

 

Riboflavin/Vitamin B2-dependent

 

 

ACAD10

 

Acyl-CoA dehydrogenase family member 10 (ACAD-10) (EC 1.3.99.-)

 

 

ACAD11

 

Acyl-CoA dehydrogenase family member 11 (ACAD-11) (EC 1.3.99.-)

 

 

ACAD8 ARC42 IBD

 

Isobutyryl-CoA dehydrogenase, mitochondrial (EC 1.3.99.-) (Acyl-CoA dehydrogenase family member 8) (ACAD-8) (Activator-recruited cofactor 42 kDa component) (ARC42)

 

 

ACAD9

 

Acyl-CoA dehydrogenase family member 9, mitochondrial (ACAD-9) (EC 1.3.99.-)

 

 

ACADL

 

Long-chain specific acyl-CoA dehydrogenase, mitochondrial (LCAD) (EC 1.3.99.13)

 

 

ACADM

 

Medium-chain specific acyl-CoA dehydrogenase, mitochondrial (MCAD) (EC 1.3.99.3)

 

 

ACADS

 

Short-chain specific acyl-CoA dehydrogenase, mitochondrial (SCAD) (EC 1.3.99.2) (Butyryl-CoA dehydrogenase)

 

 

ACADSB

 

Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial (SBCAD) (EC 1.3.99.-) (2-methyl branched chain acyl-CoA dehydrogenase) (2-MEBCAD) (2-methylbutyryl-coenzyme A dehydrogenase) (2-methylbutyryl-CoA dehydrogenase)

 

 

ACADVL VLCAD

 

Very long-chain specific acyl-CoA dehydrogenase, mitochondrial (VLCAD) (EC 1.3.99.-)

 

 

ACOX1 ACOX

 

Peroxisomal acyl-coenzyme A oxidase 1 (AOX) (EC 1.3.3.6) (Palmitoyl-CoA oxidase) (Straight-chain acyl-CoA oxidase) (SCOX)

 

 

ACOX2

 

Peroxisomal acyl-coenzyme A oxidase 2 (EC 1.17.99.3) (3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanoyl-CoA 24-hydroxylase) (3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanoyl-CoA oxidase) (Trihydroxycoprostanoyl-CoA oxidase) (THCA-CoA oxidase) (THCCox)

 

 

ACOX3 BRCOX PRCOX

 

Peroxisomal acyl-coenzyme A oxidase 3 (EC 1.3.3.6) (Pristanoyl-CoA oxidase) (Branched-chain acyl-CoA oxidase) (BRCACox)

 

 

ACOXL

 

Acyl-coenzyme A oxidase-like protein (Acyl-CoA oxidase-like protein) (EC 1.3.3.-)

 

 

AGPS AAG5

 

Alkyldihydroxyacetonephosphate synthase, peroxisomal (Alkyl-DHAP synthase) (EC 2.5.1.26) (Alkylglycerone-phosphate synthase) (Aging-associated gene 5 protein)

 

 

AIFM1 AIF PDCD8

 

Apoptosis-inducing factor 1, mitochondrial (EC 1.-.-.-) (Programmed cell death protein 8)

 

 

AIFM2 AMID PRG3

 

Apoptosis-inducing factor 2 (EC 1.-.-.-) (Apoptosis-inducing factor-like mitochondrion-associated inducer of death) (Apoptosis-inducing factor homologous mitochondrion-associated inducer of death) (p53-responsive gene 3 protein)

 

 

AIFM3 AIFL

 

Apoptosis-inducing factor 3 (EC 1.-.-.-) (Apoptosis-inducing factor-like protein)

 

 

AOX1 AO

 

Aldehyde oxidase (EC 1.2.3.1)

 

 

BLVRB FLR

 

Flavin reductase (FR) (EC 1.5.1.30) (NADPH-dependent diaphorase) (NADPH-flavin reductase) (FLR) (Biliverdin reductase B) (BVR-B) (EC 1.3.1.24) (Biliverdin-IX beta-reductase) (Green heme-binding protein) (GHBP)

 

 

CHDH

 

Choline dehydrogenase, mitochondrial (CHD) (CDH) (EC 1.1.99.1)

 

 

COQ6 CGI-10

 

Ubiquinone biosynthesis monooxygenase COQ6 (EC 1.14.13.-)

 

 

CRY1 PHLL1

 

Cryptochrome-1

 

 

CRY2 KIAA0658

 

Cryptochrome-2

 

 

CYB5R1 NQO3A2 UNQ3049/PRO9865

 

NADH-cytochrome b5 reductase 1 (b5R.1) (EC 1.6.2.2) (NAD(P)H:quinone oxidoreductase type 3 polypeptide A2) (Humb5R2)

 

 

CYB5R2

 

NADH-cytochrome b5 reductase 2 (b5R.2) (EC 1.6.2.2)

 

 

CYB5R3 DIA1

 

NADH-cytochrome b5 reductase 3 (Cytochrome b5 reductase) (B5R) (EC 1.6.2.2) (Diaphorase-1) [Cleaved into: NADH-cytochrome b5 reductase 3 membrane-bound form; NADH-cytochrome b5 reductase 3 soluble form]

 

 

CYB5R4 NCB5OR

 

Cytochrome b5 reductase 4 (EC 1.6.2.2) (Flavohemoprotein b5/b5R) (b5+b5R) (cb5/cb5R) (N-terminal cytochrome b5 and cytochrome b5 oxidoreductase domain-containing protein)

 

 

CYB5RL

 

NADH-cytochrome b5 reductase-like (EC 1.6.2.2)

 

 

CYBB NOX2

 

Cytochrome b-245 heavy chain (EC 1.-.-.-) (p22 phagocyte B-cytochrome) (Neutrophil cytochrome b 91 kDa polypeptide) (Heme-binding membrane glycoprotein gp91phox) (CGD91-phox) (gp91-phox) (gp91-1) (Cytochrome b(558) subunit beta) (Cytochrome b558 subunit beta) (Superoxide-generating NADPH oxidase heavy chain subunit) (NADPH oxidase 2)

 

 

D2HGDH D2HGD

 

D-2-hydroxyglutarate dehydrogenase, mitochondrial (EC 1.1.99.-)

 

 

DAK

 

Bifunctional ATP-dependent dihydroxyacetone kinase/FAD-AMP lyase (cyclizing) [Includes: ATP-dependent dihydroxyacetone kinase (DHA kinase) (EC 2.7.1.29) (Glycerone kinase); FAD-AMP lyase (cyclizing) (EC 4.6.1.15) (FAD-AMP lyase (cyclic FMN forming)) (FMN cyclase)]

 

 

DAO DAMOX

 

D-amino-acid oxidase (DAMOX) (DAAO) (DAO) (EC 1.4.3.3)

 

 

DDO

 

D-aspartate oxidase (DASOX) (EC 1.4.3.1) (DDO)

 

 

DHCR24 KIAA0018

 

24-dehydrocholesterol reductase (EC 1.3.1.-) (3-beta-hydroxysterol delta-24-reductase) (Seladin-1) (Diminuto/dwarf1 homolog)

 

 

DHODH

 

Dihydroorotate dehydrogenase, mitochondrial (DHOdehase) (EC 1.3.5.2) (Dihydroorotate oxidase)

 

 

DLD GCSL LAD PHE3

 

Dihydrolipoyl dehydrogenase, mitochondrial (EC 1.8.1.4) (Dihydrolipoamide dehydrogenase) (Glycine cleavage system L protein)

 

 

DMGDH

 

Dimethylglycine dehydrogenase, mitochondrial (EC 1.5.99.2) (ME2GLYDH)

 

 

DPYD

 

Dihydropyrimidine dehydrogenase [NADP+] (DHPDHase) (DPD) (EC 1.3.1.2) (Dihydrouracil dehydrogenase) (Dihydrothymine dehydrogenase)

 

 

DUOX1 DUOX LNOX1 THOX1

 

Dual oxidase 1 (EC 1.6.3.1) (EC 1.11.1.-) (NADPH thyroid oxidase 1) (Large NOX 1) (Long NOX 1) (Thyroid oxidase 1)

 

 

DUOX2 LNOX2 THOX2

 

Dual oxidase 2 (EC 1.6.3.1) (EC 1.11.1.-) (NADPH oxidase/peroxidase DUOX2) (NADPH thyroid oxidase 2) (Large NOX 2) (Long NOX 2) (Thyroid oxidase 2) (NADH/NADPH thyroid oxidase p138-tox) (p138 thyroid oxidase)

 

 

DUS1L

 

tRNA-dihydrouridine synthase 1-like (EC 1.-.-.-)

 

 

DUS2L DUS2

 

tRNA-dihydrouridine synthase 2-like (hDUS2) (EC 1.-.-.-) (Up-regulated in lung cancer protein 8) (URLC8)

 

 

DUS3L

 

tRNA-dihydrouridine synthase 3-like (EC 1.-.-.-)

 

 

DUS4L

 

tRNA-dihydrouridine synthase 4-like (EC 1.-.-.-) (pp35)

 

 

ERO1L UNQ434/PRO865

 

ERO1-like protein alpha (ERO1-L-alpha) (ERO1-L) (EC 1.8.4.-) (Oxidoreductin-1-L-alpha) (Endoplasmic oxidoreductin-1-like protein)

 

 

ERO1LB

 

ERO1-like protein beta (ERO1-L-beta) (EC 1.8.4.-) (Oxidoreductin-1-L-beta) (Endoplasmic oxidoreductin-1-like protein B)

 

 

ETFA

 

Electron transfer flavoprotein subunit alpha, mitochondrial (Alpha-ETF)

 

 

ETFB FP585

 

Electron transfer flavoprotein subunit beta (Beta-ETF)

 

 

ETFDH </