What if you could use a marker to detect your chance for death by cardiovascular disease and as a measure of your overall immune health? 


Now you can based on a study just published in July 2021 by researchers at the Buck Institute of Aging. 


Typical measures involve c-reactive protein, but this is just an acute phase reactant protein generally indicative of infections and autoimmune disease, but not immune system competence. 


The marker CXCL9 has a distinct 7-year prognostic value in predicting immunological function with cardiovascular disease associated mortality risk.[1] 


In the study over 1,000 individuals were monitored over 10+ years for measures of cardiovascular health including arterial stiffness, cardiac hypertrophy, remodeling of the heart, and more. 



"While many diseases of aging have been linked to the immunological system, immune metrics capable of identifying the most at-risk individuals are lacking. From the blood immunome of 1,001 individuals aged 8–96 years, we developed a deep-learning method based on patterns of systemic age-related inflammation. The resulting inflammatory clock of aging (iAge) tracked with multimorbidity, immunosenescence, frailty and cardiovascular aging, and is also associated with exceptional longevity in centenarians. The strongest contributor to iAge was the chemokine CXCL9, which was involved in cardiac aging, adverse cardiac remodeling and poor vascular function."


One exceptionally healthy individual in Italy that is 105y of age has CXCL9 levels of a 25y old.[2] 


If you are interested and have a cooperative physician that works with you, we can get this test done towards finding your baseline and then working to decrease your CXCL9 levels after interventions. 


It may change your life and those around you for the better and longer. 




[1] Sayed N, Huang Y, Nguyen K, Krejciova-Rajaniemi Z, Grawe AP, Gao T, et al. An inflammatory aging clock (iAge) based on deep learning tracks multimorbidity, immunosenescence, frailty and cardiovascular aging. Nat Aging 2021;1:598–615. https://doi.org/10.1038/s43587-021-00082-y.



[2] “Clock” created to predict immunological health and chronic diseases of aging: Research highlights the critical role of the immune system in the aging process. ScienceDaily n.d. https://www.sciencedaily.com/releases/2021/07/210712122159.htm (accessed August 7, 2021).