What was the sequencing of the human genome project good for?
Answer, determining gene function and at the most practical what-you-can-do level, determining which of these gene require minerals (magnesium, zinc, iron, potassium, etc...)/vitamins/amino acids/other to provide function.
This explains why for example, magnesium, is known to be required for more gene functions than any other food you ingest. It is over 800.
However, some genes are essential to basic cellular life and in some examples, the research describing the mechanisms of active depletion are well understood. This is particularly true of vitamin B3 (niacin or niacinamide or niacinamide riboside).
The zebrafish animal model was pioneered in large part in the 1990s because researchers could for the first time use this model to determine all of the genes that are essential required for development of the vertebrate animal model. Large numbers were mutated randomly and bred to make homozygous mutants, which were screened for 1:4 mutants, and genes were mapped. Development, volume 123.